Simparica TRIO for Dogs

(499)

Simparica TRIO for Dogs

Simparica TRIO is a once-a-month, liver-flavored chew that delivers broad parasite protection in one convenient dose. It helps prevent heartworm disease, a serious condition spread by mosquitoes, while also treating and controlling roundworms and hookworms. In addition, it kills fleas and ticks and helps protect against tapeworm infections that can result from flea exposure. As heartworm disease has been diagnosed in all 50 states, consistent, year-round prevention is an important part of your dog’s care routine. With a single monthly chew, Simparica TRIO simplifies parasite protection, helping pet parents support their dog’s health with reliable, veterinarian-recommended coverage.

How It Helps

Simparica TRIO works by combining trusted ingredients (sarolaner, moxidectin, and pyrantel) to protect your dog from multiple parasites at once. It provides 100% protection against heartworm disease when given monthly. It starts killing fleas within 4 hours and achieves full effectiveness within 8 hours, helping stop infestations before fleas can lay eggs. It also treats and controls roundworms and hookworms and helps prevent flea tapeworm infections by eliminating fleas. In addition, it protects against six species of ticks (Gulf coast tick, American dog tick, Lone star tick, Black-legged tick or Deer tick, Brown dog tick, and Asian longhorned tick) for a full month, including the deer tick that may carry Lyme disease.

Who It’s For

• Dogs and puppies 8 weeks of age and older
• Dogs weighing at least 2.8 lbs
• Suitable for small, medium, and large breeds (weight-based dosing available)

Why Pet Parents Choose It

• Prevents heartworm disease with monthly dosing
• Kills fleas before they can lay eggs
• Starts killing fleas within 4 hours
• Protects against 6 species of ticks for one full month
• Treats and controls roundworms and hookworms
• Helps prevent flea tapeworm infections
• Highly palatable liver flavor
• FDA-approved combination preventive

How to Use

• Have your dog tested for heartworm infection before starting prevention.
• Give one chewable tablet by mouth once every month.
• Administer on the same date each month for consistent protection.
• Use year-round to maintain continuous parasite prevention.
• The chew can be given with or without food.
• Ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.
• If a dose is missed, give another dose immediately and resume monthly dosing.

Dosage:

Safety & Care Tips

• Read the labeled information carefully before use.
• Not for use in humans.
• For dogs 8 weeks of age and older weighing at least 2.8 lbs.
• Dogs should be tested for heartworm infection prior to starting.
• Use only as directed by your veterinarian.
• To prevent flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
• The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.
• Use with caution in dogs with history of seizures, or neurologic disorders.
• Keep out of reach of children and other pets.
• Speak with your veterinarian if your dog has a history of health concerns.
• Store below or at 30°C (86°F).

• Sarolaner
• Moxidectin
• Pyrantel

Available Pack Sizes

• 3-dose pack
• 6-dose pack
• 12-dose pack
• Available in multiple weight-based strengths and convenient monthly pack options to suit your dog’s size and needs:

Frequently Asked Questions

1. How is Simparica TRIO different from other preventives?

Simparica TRIO is a monthly chew that helps protect against heartworm disease, six species of ticks, fleas, roundworms, hookworms, and flea tapeworm infections—all in one dose. It can be given with or without food, so you can administer it at a time that works best for your routine.

2. Is Simparica TRIO safe?

Simparica TRIO has been demonstrated safe for dogs and puppies 8 weeks of age and older, weighing at least 2.8 lbs, when used as directed.

3. How often should I give Simparica TRIO?

Give one chew once every month to maintain consistent protection.

4. How do I switch from another heartworm, flea, or tick medication?

Speak with your veterinarian before switching. They can guide you on timing to ensure continuous parasite protection.

5. What if I’m late giving a dose?

If a dose is missed, give it as soon as possible and resume your monthly schedule. If a dose is vomited or spit out, administer another full dose and continue as directed.

6. How fast does Simparica TRIO start working?

It begins killing fleas within 4 hours and starts killing deer ticks within 8 hours.

7. When can I start Simparica TRIO for my puppy?

You can begin using it in puppies as young as 8 weeks old who weigh at least 2.8 lbs.

8. Can Simparica TRIO help prevent Lyme disease?

Simparica TRIO is FDA-approved to help prevent infections that may cause Lyme disease by killing deer ticks.

9. How does it help prevent flea tapeworm infections?

By killing fleas, Simparica TRIO helps prevent flea tapeworm infections. Dogs can become infected by swallowing fleas that carry tapeworm larvae, so effective flea control is an important part of prevention.