Simparica TRIO Chewable Tablets for Dogs 11.1-22 lbs (Caramel)

Simparica TRIO Chewables for Dogs and Puppies 11.1–22 lbs (Caramel Pack) is formulated for small dogs and puppies 8 weeks of age and older weighing between 11.1–22 lbs. This Caramel color pack, once-monthly, liver-flavored chew contains 12 mg sarolaner, 0.24 mg moxidectin, and 50 mg pyrantel to provide broad parasite protection. It helps prevent heartworm disease, kills fleas, treats and controls roundworms and hookworms, and protects against tick infestations, including deer ticks that may carry Lyme infections. By eliminating fleas, it also helps prevent flea tapeworm (Dipylidium caninum) infections. Given once a month as directed by your veterinarian, it offers accurate, weight-specific protection for small dogs.

How It Helps

Simparica TRIO works by combining trusted ingredients (sarolaner, moxidectin, and pyrantel) to protect your dog from multiple parasites at once. It provides 100% protection against heartworm disease when given monthly. It starts killing fleas within 4 hours and achieves full effectiveness within 8 hours, helping stop infestations before fleas can lay eggs. It also treats and controls roundworms and hookworms and helps prevent flea tapeworm infections by eliminating fleas. In addition, it protects against six species of ticks (Gulf coast tick, American dog tick, Lone star tick, Black-legged tick or Deer tick, Brown dog tick, and Asian longhorned tick) for a full month, including the deer tick that may carry Lyme disease.

Who it’s for

Small dogs and puppies 8 weeks of age and older, weighing between 11.1–22 lbs

Your veterinarian can help determine the correct dosage based on your dog’s current weight.

Why Pet Parents Choose It

Prevents heartworm disease with monthly dosing
Kills fleas before they can lay eggs
Starts killing fleas within 4 hours
Protects against 6 species of ticks for one full month
Treats and controls roundworms and hookworms
Helps prevent flea tapeworm infections
Highly palatable liver flavor
FDA-approved combination preventive

How to Use

Have your dog tested for heartworm infection before starting prevention.
Give one chewable tablet by mouth once every month.
Administer on the same date each month for consistent protection.
Use year-round to maintain continuous parasite prevention.
The chew can be given with or without food.
Ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.
If a dose is missed, give another dose immediately and resume monthly dosing.

Dosage:

Dog weight (lbs.)	Pack color	Sarolaner per tablet (mg)	Moxidectin per tablet (mg)	Pyrantel per tablet (mg)	Number of tablets administered
2.8 – 5.5	Yellow	3	0.06	12.5	One
5.6 to 11	Purple	6	0.12	25	One
11.1 to 22	Caramel	12	0.24	50	One
22.1 to 44	Blue	24	0.48	100	One
44.1 to 88	Green	48	0.96	200	One
88.1 to 132	Brown	72	1.44	300	One
>132	Administer the appropriate combination of tablets

Safety & Care Tips

Read the labeled information carefully before use.
Not for use in humans.
For dogs 8 weeks of age and older weighing at least 2.8 lbs.
Dogs should be tested for heartworm infection prior to starting.
Use only as directed by your veterinarian.
To prevent flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.
The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.
Use with caution in dogs with history of seizures, or neurologic disorders.
Keep out of reach of children and other pets.
Speak with your veterinarian if your dog has a history of health concerns.
Store below or at 30°C (86°F).

Active Ingredients :

Sarolaner
Moxidectin
Pyrantel

Available Pack Sizes

3-dose pack
6-dose pack
12-dose pack
Available in multiple weight-based strengths and convenient monthly pack options to suit your dog’s size and needs:

Product Name	Pet Size	Pet Weight	Color Code
Simparica TRIO	Very Small	2.8–5.5 lbs	Yellow
Simparica TRIO	Extra Small	5.6–11 lbs	Purple
Simparica TRIO	Small	11.1–22 lbs	Caramel
Simparica TRIO	Medium	22.1–44 lbs	Blue
Simparica TRIO	Large	44.1–88 lbs	Green
Simparica TRIO	Extra Large	88+ lbs	Brown

Frequently Asked Questions

1. How is Simparica TRIO different from other preventives?

Simparica TRIO is a monthly chew that helps protect against heartworm disease, six species of ticks, fleas, roundworms, hookworms, and flea tapeworm infections—all in one dose. It can be given with or without food, so you can administer it at a time that works best for your routine.

2. Is Simparica TRIO safe?

Simparica TRIO has been demonstrated safe for dogs and puppies 8 weeks of age and older, weighing at least 2.8 lbs, when used as directed.

3. How often should I give Simparica TRIO?

Give one chew once every month to maintain consistent protection.

4. How do I switch from another heartworm, flea, or tick medication?

Speak with your veterinarian before switching. They can guide you on timing to ensure continuous parasite protection.

5. What if I’m late giving a dose?

If a dose is missed, give it as soon as possible and resume your monthly schedule. If a dose is vomited or spit out, administer another full dose and continue as directed.

6. How fast does Simparica TRIO start working?

It begins killing fleas within 4 hours and starts killing deer ticks within 8 hours.

7. When can I start Simparica TRIO for my puppy?

You can begin using it in puppies as young as 8 weeks old who weigh at least 2.8 lbs.

8. Can Simparica TRIO help prevent Lyme disease?

Simparica TRIO is FDA-approved to help prevent infections that may cause Lyme disease by killing deer ticks.

9. How does it help prevent flea tapeworm infections?

By killing fleas, Simparica TRIO helps prevent flea tapeworm infections. Dogs can become infected by swallowing fleas that carry tapeworm larvae, so effective flea control is an important part of prevention.