Frontline Plus

Frontline Plus for Large Dogs 44 to 88lbs (Purple)

Reviews: 326
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Frontline Plus Purple Pack for Large Dogs (45 - 88lbs)

Frontline Plus flea & tick spot-on treatment for large dogs is a remarkable topical solution for dogs. It is a safe spot-on solution that’s easy to apply to your pet’s skin. Not only does it kill fleas and ticks, it stops their eggs from hatching and breaks the rapid lifecycle that causes infestation in your home. It is available in four different pack sizes for convenient use. Frontline Plus purple for large dogs pack is designed specifically for dogs weighing between 45-88 lbs. It has been formulated with the combination of two active ingredients for dogs eight weeks of age and older.

The combination of two active ingredients - Fipronil and (S) -methoprene, magically work to kill fleas within 12 hours and ticks within 48 hours of application. Fipronil kills adult fleas and ticks, and the other chemical (S)-methoprene breaks flea life cycle by attacking flea eggs and larvae. It is an easy to use topical application that stores in the oil glands of pet's skin and works for 30 days. Unlike other flea treatments, it also helps to reduce the risk of tick-borne disease transmission.


Fipronil; (S)Methoprene


Merial / Boehringer Ingelheim
  • Frontline Plus is an effective topical solution that treats various external parasites
  • Quick in its action, it removes fleas within 12 hours of application
  • It destroys the life cycle of flea along with killing its various stages
  • It effectively works for a month not allowing fleas and ticks to attack for re-infestation
  • It successfully fights against deer ticks, brown ticks, lone star ticks and American dog ticks
  • Frontline Plus also guards dogs against flea allergy dermatitis (FAD)
  • The waterproof property makes it efficient even when a dog goes for swimming or has a bath
  • Weigh dog before treating with a Frontline Plus.
  • Make dog stand in a comfortable position to apply the solution.
  • On the back of your pet, part the fur between the shoulder blades where the dog cannot lick.
  • Remove pipette from the pack and break the seal. Place the tip of the pipette on the located spot without touching hair.
  • Squeeze and empty the entire content at the spot.
  • Be careful not to touch the area until the application is wet.
  • For small and medium dogs, apply at single spot.
  • For large dogs, apply at 4-5 spots starting from the place between the shoulder blades and reaching the base of the tail.
  • It is suitable for nursing, breeding and pregnant dogs.
  • For old, debilitated and pets on other medications, consult a veterinarian.


Dosage as per dog size:

Color Code (pack color)


Dog Size


0.67 ml

0-22 lbs


1.34 ml

23-44 lbs


2.68 ml

45-88 lbs


4.02 ml

89-132 lbs

  • Frontline Plus is advisable for 8 weeks and older puppies and dogs.
  • Frontline Plus for dogs is strictly not recommended for felines.
  • Keep away from children and pets, and other animal feeds.
  • Store it in a cool and dry place away from direct flame and heat.
  • Consult a vet before treating aged, injured, debilitated dogs and pets that are on medication.
  • If swallowed accidently, contact poison control center or your physician immediately.
  • Avoid direct contact with eyes. If it enters, wash with running water for few minutes.
  • After treating dog, wash hands with soap and water.

Ratings & Reviews

Based on 326 Review(s)

Average Rating


Ratings Overview










Most Recent Reviews
  • Cookie
    Best flea and tick treatment
    Mar 29, 2023

    Our vet recommended this and now I dont have to worry about my doing going out in the park or in the woods.

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  • Cookie
    #1 product
    Mar 23, 2023

    #1 treatment for flea and tick protection in dogs

    1 of 1 found this review helpful.
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  • Cookie
    Highly recommend
    Mar 13, 2023

    Worked well for my hounds.

    1 of 2 found this review helpful.
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  • Cookie
    Mar 07, 2023

    Keeps your dog protected from fleas and ticks. Just make sure you dose regularly.

    1 of 1 found this review helpful.
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  • Cookie
    Feb 27, 2023

    Cost effective and works perfectly!

    1 of 1 found this review helpful.
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FAQ On Frontline Plus
Q. How safe is Frontline Plus for dogs?

A. Frontline Plus for Dogs is totally safe for all sizes and breeds of dogs. When applied monthly, it protects against parasitic infestation without any harm to your dog.

Q. How does FRONTLINE Plus kill fleas and ticks?

A. Frontline Plus contains two strong ingredients. Fipronil – a potent adulticide and (S)-Methoprene – an insect growth regulator. Once the treatment given, the strong ingredient - Fipronil triggers the nerve cells of fleas and ticks resulting into paralysis of these pests. Eventually, these parasites are destroyed. The ingredient (S)-Methoprene inhibits the growth of flea eggs and larvae. Thus, these are eliminated.

Frontline Plus easily spreads through oil glands in your pet’s skin. Slowly, it is distributed continuously for one month to your pet’s hair and skin through hair follicles. It continuously works against fleas and ticks.

Q. How quickly does Frontline Plus work on fleas and ticks?

A. Frontline Plus is a fast acting formula. It starts killing fleas 4 hours after application. It removes 100% fleas within 24 hours and ticks within 48 hours.

Q. How long Frontline Plus should be applied for before exposure to water?

A. Frontline Plus is water resistant. After application, keep your pet from getting wet for 48 hours. If you want to apply after bath, ensure that your pet is completely dry before application. It remains effective for 30 days, even if your pet swims or is bathed.

Q. Can I apply it more than once a month?

A. Frontline Plus is a monthly treatment. Therefore, it is not advisable to apply the spot-on within a month. You can re-apply after 30 days.

Q. Can I use Frontline Plus along with another flea and tick products?

A. Frontline Plus alone is powerful in treating fleas and ticks. It is better not to use any other topical flea and tick treatment along with Frontline Plus.