Hold the applicator in upright position away from your face and snap open its tip by folding it. Keep the dog in standing position. Part the coat between the shoulder blades and squeeze entire contents of the applicator onto the skin evenly. Do not allow product to overspill. For very small and small dogs, apply at one spot. For medium, large and very large dogs, apply at two, three and four spots respectively along the shoulder blade. Repeat every 30 days.